Keynote Speakers


Eva Lee
Virginia C. and Joseph C. Mello Chair and Professor,
H. Milton Stewart School of Industrial and Systems Engineering, Georgia Tech, USA


Doheon Lee
Director of Bio-Synergy Research Center and Professor,
Korea Advanced Institute of Science and Technology, Korea

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Prof. Eva Lee, H. Milton Stewart School of Industrial and Systems Engineering at Georgia Tech, also serves as the Director of the Center for Operations Research in Medicine and HealthCare. She is also a Senior Research Professor at the Atlanta VA Medical Center. Dr. Lee works in the area of mathematical programming and large-scale computational algorithms with a primary emphasis on medical/healthcare decision analysis and logistics operations management. She tackles challenging problems in health systems and biomedicine through systems modeling, algorithm and software design, and decision theory analysis. Specific research areas include health risk prediction, early disease prediction and diagnosis, optimal treatment strategies and drug delivery, healthcare outcome analysis and treatment prediction, public health and medical preparedness, large-scale healthcare/medical decision analysis and quality improvement. Dr. Lee's research in logistics focuses on large-scale optimization and algorithmic advances for optimal operations planning and resource allocation. She has developed decision support systems for inventory control; large-scale truck dispatching, scheduling, and transportation logistics; telecommunications; portfolio investment; and emergency treatment response and facility layout and planning. Dr. Lee was awarded a NSF/NATO postdoctoral fellowship on Scientific Computing, and a postdoctoral fellowship from Konrad-Zuse-Zentrum Informationstechnik Berlin in 1995 for Parallel Computation. In 1996, she received the NSF Presidential Young Investigator Award for research on integer programming and parallel algorithms and their applications to medical diagnosis and cancer treatment. She was the first OR/IE recipient for the prestigious Whitaker Foundation Biomedical Grant for Young Investigators, awarded for her work on a novel approach for combining biological imaging and optimal treatment design for prostate cancer. In 2004, she was selected as one of the Extraordinary Women Engineers. In 2005, she received the INFORMS Pierskalla award for research excellence in HealthCare and Management Science for her work on emergency response and planning, large-scale prophylaxis dispensing, and resource allocation for bioterrorism and infectious disease outbreaks. In 2006, she was chosen by the American Mathematical Society as the representative mathematician to speak and discuss individually with congressional leaders about her research advances in the medical and healthcare domain, and about the importance of mathematics in scientific advances. Together, Lee and Dr. Marco Zaider from Memorial Sloan-Kettering Cancer Center were named winners of the 2007 Franz Edelman award for their work on using operations research to advance cancer therapeutics. Lee has received seven patents for innovative medical systems and devices. Her research has been featured and discussed in numerous news media articles, including articles in the New York Times, London Times, Urology Times, Atlanta Business Chronicle, and Homeland Security IAIP Directorate Daily Report. Her cancer research was featured in a TV science news segment for Discoveries and Breakthroughs, Inside Science, Curing Prostate Cancer, broadcast by television stations nationwide.

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Abstract: Formidable complexity of systemic human physiology often give rises of unintended effects of therapeutic compounds during the drug development processes or even after the drug approvals. Though the beneficial unintended effects could lead opportunities of repositioning drugs, the harmful effects might put critical hurdles against successful drug development. We have been developing a virtual human system, CODA, which can explore functional effects of therapeutic compounds in the systemic level. CODA integrates three types of physiological knowledge from public structured databases, literature, and in-house experiments into a unified format of physiological interactions. More than ten public databases including KEGG, GO, and CTD have been transformed; around 25 million PUBMED abstracts have been text-mined; and more than 5,000 in-house novel findings have been incorporated. We have also developed two types of analysis on the CODA knowledge repository. Given therapeutic compounds of interest, CODA can identify possible phenotypic effects in the systemic level. When therapeutic compounds and their observed functional effects are given, CODA can enumerate possible effect paths encompassing molecular, functional, and disease level interactions. We have been testing CODA by applying it to various tasks including drug repositioning, drug-drug interactions, and side effect prediction with known benchmark datasets. Though we are enriching CODA with more knowledge sources and more sophisticated analysis techniques, the current version is already providing unique analysis capabilities and one of the most comprehensive information for drug discovery.

Prof. Doheon Lee is Professor in the Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology and Director of Bio-Synergy National Research Center, Korea. He also serves as the President of Korean Society for Bioinformatics. Doheon Lee received the B.S., M.S., and Ph.D. degrees in computer science from Korea Advanced Institute of Science and Technology (KAIST), Korea, in 1990, 1992, and 1995, respectively. He was a visiting professor of Stanford University, Indiana University, Translational Genomics Research Institute (TGEN) and Univ. of Texas at Austin, USA. Currently, he is a professor in Department of Bio and Brain Engineering, KAIST, and the director of Bio-Synergy Research Center (BSRC), a Korean national project where over 30 principal investigators are collaborating for natural product bioinformatics and systems biology. He was an Associate Editor for ACM Transactions on Internet Technology for nine years. He is also serving Scientific Reports, International Journal of Data Mining in Bioinformatics, and Healthcare Informatics Research as an Editorial Board Member. He is a co-founder of ACM International Workshop on Data and Text Mining for Biomedical Informatics. He has published over 200 academic papers in bioinformatics, medical informatics, neuroinformatics, and data mining.